Anal fissures are depicted as a scratch in the lining of the lower rectum portion that is supposed to cause unbearable pain during bowel movements. Anal fissures can occur due to the passing of hard stools, constipation, repeated diarrhea, or child birth. The most commonly occurring symptoms that show that anal fissures have occurred include itching, burning sensation during a bowel movement, bleeding when passes stools. Anal fissures can be described as acute or chronic one.

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Acute anal fissures: These are short-term problems in the lining of the anal canal that can be cured with some home remedies.

Chronic anal fissures: These are long-term anal fissures that are not healed even after 8 to 12 weeks. These are then to be treated with some medications.    

Medications meant to be used to treat anal fissures:

Following are some of the commonly known medication that can be used to treat chronic anal fissures:

  • Ointments containing anaesthetics
  • Steroids
  • Nitroglycerin
  • Calcium channel blocking drugs (CCBs)

Among them, Nitroglycerin is the common and best suited one. Read the blog blue to gather more about Nitroglycerin ointment meant for treating anal fissures.

Nitroglycerin ointment is the topical medicament meant for the use in the management of anal fissures. The person who faces any symptoms of anal fissures can use this medicine as this medicine is counted on the first medication for healing anal fissures.            

Nitro-glycerine gets converted to nitric oxide (NO) that activates the enzyme guanylate cyclase. This encourages the creation of cGMP that further promotes a series of protein kinase-dependent phosphorylation in the smooth muscle cells. This causes the dephosphorylation of the myosin light chain of the smooth muscle fibre and leads to the discharge of calcium ions resulting in the relaxation of the smooth muscle cells and vasodilation.

0.2% Nitroglycerin ointment is meant to be used to treat long term anal fissures.

A small amount of this ointment is to be used twice a day to get relief from anal fissures within day’s duration. Do not apply for the medicine without washing your hands either it is advised to wear gloves during the application of the medicine. Do clean the anal portion and tap dry before applying the ointment.

Precautionary tips with Nitroglycerin ointment:

  • Do not use this ointment for a longer duration as this may make enhance your tolerance to the therapeutic effect of the medicine.
  • This medicine may lower blood pressure so do not use within 24 hours of using any erection-treating medicine.
  • Do not use before doing any task that needs proper alertness and concentration.
  • The elder people above the age of 65 years should use this medicine with plenty of care.
  • The pregnant and lactating mothers are supposed to use this medicine only if advised by their doctors.
  • Do not use this ointment in case you are hypersensitive to any of the component of the medicine.


Noxious side issues with Nitroglycerin ointment:

 A number of side effects come along with the therapeutic use of the medicine. Some of them include:

  • Flushing
  • Nausea, vomiting, headache
  • A headache
  • Itching or burning sensation after application
  • Restlessness


Storage conditions:
Do keep the medicine at a dry place at room temperature and away from the reach of children.

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