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Generic: BRIMONIDINE (bri-MOE-ni-deen)+TIMOLOL (TIM-oh-lole)

Manufacturer: RSM/Dhadha

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Combigan eye drop is a trusted treatment for managing open angle glaucoma and raised pressure in the eye (ocular hypertension). It is a prescription medicine that contains two active ingredients, brimonidine tartrate and timolol maleate. Both these medicines help to decrease raised pressure within the eye and works to provide relief to the patient. However, this treatment does not cure the problem but provides relief in the symptoms. Due to combined effect of both these medicines symptoms get better as compared to individual treatment from each one on its own. 

What is Combigan eye drop? How it works?

Combigan eye drop is the fine combination of two different medicines i.e. brimonidine, an alpha agonist and Timolol, a beta-blocker. Both these medicines help to decrease raised pressure within the eye and works to provide relief to the patient. Brimonidine shows healing effect by reducing the inflow of aqueous humour into the eyeball, and in this way the helps to lessen the pressure within the eye. The other ingredient, Timolol also blocks the beta receptors in the eye and helps to decrease the quantity of aqueous humour produced. In this way both ingredients works simultaneously to provide relief to the patient.

What are the medical conditions for which this treatment is used?

  • Open angle glaucoma
  • Raised pressure in the eye (ocular hypertension)

This treatment may be used for other conditions as well, that are not included here. Ask your doctor to know more about your health condition if you are suggested with Combigan eye drops.


What are the medical conditions in which using this treatment is not permitted?

In following health conditions Combigan treatment should not be used. If a person is diagnosed with or already suffering from

  • bronchial asthma,
  • severe chronic obstructive pulmonary disease
  • sinus bradycardia
  • atrioventricular block
  • overt cardiac failure
  • cardiogenic shock
  • hypersensitive to any ingredient of this medicine

Other than the above, this treatment is not recommended in neonates and infants (under the age of 2 years). Adding to it, it should be used with caution is children above two years of age.


What are the warnings and precautions associated with this treatment?

The treatment with Combigan should be used with caution if patient is suffering from any of these health conditions:

  • Potentiation of Respiratory Reactions Including Asthma
  • Cardiac Failure
  • Obstructive Pulmonary Disease
  • Potentiation of Vascular Insufficiency
  • Increased Reactivity to Allergens
  • Potentiation of Muscle Weakness
  • Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus
  • Masking of Thyrotoxicosis
  • Ocular Hypersensitivity

Is this treatment safe to be used in females who are pregnant or breast feeding?

Pregnant Females: Combigan medicine is not recognized as safe to be used during pregnancy. The medication may get absorbed by the bloodstream and could harm the fetus. For this reason, if you are pregnant take this medicine after consulting your doctor.

Breast feeding Mothers: The effect of Combigan on breast feeding mothers is safe or not is not known. However, it is suspected that this medication may pass into breast milk and affect the health of baby. Breast feeding mothers should take advice from healthcare provider before using this eye drops for any health benefits.


What are the side effects that can occur?

Combigan treatment does not cause any side effect on a larger note. The most common side effects associated with these eye drops include hyperaemia in which patient’s eyes become red due to increased blood supply and burning sensation in the eye.

Every medicine affects individual people in different ways and can cause different side effects. However, side effects do not occur in every patient or some may get mild side effects. If you notice anything unusual after starting any new treatment, consult your doctor.  Some of the common side effects associated with Combigan include the followings:

  • eye stinging
  • itching in the eye
  • eye irritation
  • dryness, pain or discharge from eyes
  • conjunctivitis
  • Inflammation of the eyelids (blepharitis).
  • Corneal erosion

This is not the complete list. You might get other troublesome symptoms that are not included here. So, if you find anything troublesome or unusual, talk to your doctor.

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