Paraflex 250 MG

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Paraflex 250 MG

Generic: Chlorzoxazone Tablets

Manufacturer: Cipla

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PARAFLEX (chlorzoxazone) is a muscle relaxant used to treat spasms of muscles. It is used along with physical therapy and in various muscular injuries.  Its active ingredient is chlorzoxazone which blocks signals responsible for pain. It does not act directly on the muscles but acts on central nervous system. It can also be used in some allergic conditions.

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 Chlorzoxazone is a centrally-acting drug for painful musculoskeletal conditions. It acts primarily at spinal cord and subcortical areas of the brain and inhibits the mechanism responsible for spasm of skeletal muscle. This results in reduction of the skeletal muscle spasm with relief of pain and thus increases movement of the involved muscles.

 It inhibits the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), both of which are responsible for allergic reactions. It also reduces the release of inflammatory leukotrienes. It causes inhibition of nerve signals and act as muscle relaxant by its feature of inhibiting calcium and potassium influx.


PARAFLEX is used for the management of painful musculoskeletal conditions. It relaxes the muscles. It is also used in the treatment of asthma and allergic rhinitis. Chlorzoxazone ophthalmic solution is used to treat conjunctivitis


Dosage depends on the indication and severity of disease. PARAFLEX oral tablets are available in two strengths:

  • PARAFLEX oral tablets 250 mg
  • PARAFLEX oral tablets 500 mg

Follow the dosage regimen prescribed by your doctor.


 Take the medicine three or four times a day with or without food, as prescribed by your doctor. In case you feel any irritation in stomach then take it with food. If you forget to take the medicine of the day take it as soon as you remember but do not double the dose on next day. Leave the dose of last day and take your regular dose. Tell your doctor if you are not getting any benefit from.


Common side effects are nausea, drowsiness, fatigue, body discomfort, light headedness, nervousness, muscle weakness. These are minor side effect and do not require any immediate medical attention.

Some rare but serious side effects are:

  • Allergic reaction to the drug resulting in redness/itching, swelling of lips/ throat/neck, rashes and difficulty in breathing.
  • Signs of infection like fever and sore throat
  • Symptoms of liver disease like yellowing of eyes/skin, dark urine, stomach pain, pale stools, loss of appetite
  • Confusion
  • Black stools or blood in stools
  • Vomiting that looks like coffee ground


If you are taking some other drugs during therapy with PARAFLEX, there might be chances of interaction. Here is a list of few drugs that can interact with PARAFLEX.

  • Other CNS depressants like anti-anxiety drugs (Alprazolam, Diazepam, Zolpidem, Meprobamate)
  • anti allergices (Cetrizine, Diphenhydramine)
  • other muscle relaxants
  • Narcotic pain relievers like codeine
  • Sodium oxybate (GHB)

All above mentioned medicines are sedative in nature so when taken with PARAFLEX they have additive sedative action and decreases alertness to a major extent. This list of drugs is inadequate. There are other drugs that can interact. So inform your doctor about all the medicines you are using.


  • Tell your doctor if you are having liver disease before using PARAFLEX. You may need careful monitoring. In case of increased liver enzymes in the body the drug should be discontinued.  
  • If you have allergy to chlorzoxazone tell your doctor.
  • Before using this medication, tell your doctor or pharmacist your medical history like if you are having kidney disease, mental or mood disorders (schizophrenia)and brain disease (seizures, strokes).
  • If you have a blood disease called Porphyria tell your doctor.
  • If you are pregnant, this medicine should only be used when benefits are more than risks. Always tell your doctor if you are pregnant. It should not be used in women of child bearing age without doctor’s consultation.
  •  If you are breastfeeding then tell your doctor before using PARAFLEX.
  •  Do not drive or do any work that requires alertness after taking it.
  • If you are taking any other sedative medicine then always remember that is also a sedative and if you are taking both of them together you can feel severe drowsiness. Always tell your doctor about the medicines you are using.
  • Do not drink alcohol while you are on a therapy with. When combined with alcohol can cause severe lack of alertness.
  • Should be used in children and elderly only with the prescriptions of doctor.
  • Do not take it without prescription of doctor.


Symptoms of over dosage are:

  •  gastrointestinal disturbances such as nausea, vomiting or diarrhoea
  • Severe drowsiness, dizziness
  •  Headache
  •  loss of muscle tone and  involuntary movement
  • rapid, irregular respiration
  • blood pressure is lowered

If you observe any of the above mentioned symptoms seek medical attention without any delay.

Treatment of over dosage:

  • Gastric lavage or induction of vomiting should be carried out, followed by administration of activated charcoal.
  • If there is irregular or shallow breathing, oxygen and artificial respiration should be given.
  • Lowered blood pressure can be treated by administration of dextran, plasma, concentrated albumin or a vasopressor agent such as nor epinephrine. (Analeptic or cholinergic drugs should not be used)


 PARAFLEX should be stored at controlled room temperature 15º-30ºC (59º-86ºF). Properly discard this product when it is expired or no longer required.